Endocrine Abstracts

Background: Adult craniopharyngioma (CP) patients without GH therapy exhibit high risk for cardiovascular disease (CVD) and mortality with a higher risk in women than in men. Approximately 50% of children treated for CP are obese at follow-up and hypothalamic damage seems to be a major cause. In GHD CP children GH treatment improves linear growth but does not ameliorate weight gain, but the impact of long-term GH therapy into adulthood is presently unknown.<p class="abstex...

Survivors of childhood (CO) ALL treated with prophylactic cranial radiotherapy (CRT) often exhibit (GHD) and increased cardiovascular risk. The aim of this study was to evaluate the effect of 4 years of GH therapy on cardiovascular risk factors in 16 former ALL patients and to compare them with matched population controls after 4 years.Sixteen former CO ALL patients (women=8), aged 24–37 years, treated with CRT (18–24 Gy) and chemotherapy with ...

Polycystic ovarian syndrome presents in 4–8% of women worldwide, making it the most common reproductive age endocrinopathy. Rheumatological concomitant diseases are extremely rare in PCOS patients, especially Raynaud’s phenomenon. Condition that, lowers the quality of life in patients, suggesting hormonal imbalances despite years of treatment. Studies show that oestrogen plays a role in the vasculature, it is exogenous administration increases the endothelium depende...

Type 2 5’-deiodinase (DIO2) is a common enzyme between thyroid and eye muscle tissues involving in T4 conversion to T3. The role of DIO2 has been demonstrated in the development of skeletal muscle. Increased DIO2 activities was connected to eye muscle enlargements in hyperthyroid Graves’ ophthalmopathy. In this study, the presence of antibodies against human eye muscle tissue fractions with the binding to DIO2 peptide was investigated and measur...

Th17 cells represent newly discovered CD4+T cells producing predominantly IL17A cytokines, which are involved in inflammations and autoimmune diseases. Elevated IL17 levels were demonstrated in thyroid autoimmunity and the activity of Graves’ ophthalmopathy. The relationship among IL17A, anti-thyroid antibodies, smoking, and clinical activity score of ophthalmopathy was investigated in hyperthyroid Graves’ disease. One hundred and thirty-eight patients, 62 with Grave...

Proinlfammatory cytokines, such as interleukin 17 (IL17) are involved in different inflammatory events causing cardiovascular diseases, osteoporosis and/or infertility. 1,25-dihydroxyvitamin D3 (vitamin D3) plays an immunomodulatory role and therefore, vitamin D3 deficiency can propagate the development of autoimmune diseases, infections and cancers.The effect of vitamin D3 on proinflammatory cytokine levels, s...

Adipose tissue acts as a metabolically dynamic endocrine organ secreting several hormones, cytokines, chemokines and growth factors. Resistin plays a role in inducing insulin resistance and inflammation mediated by IL6 and MCP1 cytokines. Polycystic ovarian syndrome (PCOS), pituitary adenoma (PA) and obesity disorders are characterized by insulin resistance and different hormonal-metabolic processes.The increased occurrence of proinflammatory IL17, IL6 a...

Introduction: Adrenal incidentaloma is a problem with increasing importance. There are CT-density and washout criteria for distinction between adrenal adenoma and other tumours, there are well established protocol of screening for malignancy and/or hormonal dysfunction. But there remains small portion of atypical adenoma where detailed diagnostic is needed. One relatively new option is endosonography-guided fine-needle aspiration biopsy.Aim: To assess va...

Postmenopausal osteoporosis is characterized by lower bone mass, loss of structural integrity, and sometimes becomes life-threatening. The development of postmeno-pausal osteoporosis is multifactorial. Estrogen plays a preventing role in the bone resorption inhibiting the secretion of proinflammatory IL1 and TNFα cytokines. IL17 proinflammatory citokine is a new candidate in the pathogenesis of osteoporosis. IL17 levels are increased in estrogen deficiency.<p class="a...

Background: In order to support patients with lifelong chronic illness, such as pituitary disorders, it is a challenge to continuously offer high quality of care.Aim: The aim of this study was to examine how patients with pituitary disorders of different causes perceive quality of care in contact with a specialized endocrinology reception.Methods and materials: Randomly selected, patients with chronic pituitary disorders (n=...